KIO-201 is based on hyaluronic acid (HA), a naturally-occurring polymer that is important in many physiological processes, including wound healing, tissue homeostasis, and joint lubrication.

KIO-201 is a form of Hyaluronic Acid wherein the HA is modified and then crosslinked, improving the durability and residence time on the ocular surface.

KIO-201 is an eye drop and provides a thin coating to the surface of the eye, serving as a protectant to facilitate and accelerate corneal re-epithelization. It is being developed for the management of corneal epithelial defects and for the re-epithelization of the ocular surface following surgery, under both traumatic and non-traumatic conditions.

Eye Exam Photo

Additionally, cross-linking allows the product’s viscosity to be modified to meet optimum ocular needs. The increased viscosity and non-covalent muco-adhesive interfacial forces improve residence time in the tear film, thus providing a coating that aids and promotes re-epithelization of the ocular surface via physical protection. KIO-201 provides significant mechanical improvement over non-cross-linked hyaluronic acid products and other hydrogels by forming a degradation-resistant coating.

These therapeutics are still in development and are not yet approved for commercial use.